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321 Recognition-memory impairment in an AD mouse model (5xFAD) can be accelerated by high-fat obesogenic diet by increasing blood levels of the metabolite N-acetylneuraminic acid (NANA), which results in systemic immune exhaustion

This decline is the basis for much of the research interest in GHK-Cu spray, since restoring exogenous copper-peptide complex is thought to reactivate signaling pathways that quiet down over time

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Hollestein et al., 2021, p