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Studies indicate that demyelination in the inner prefrontal cortex (PFC) and diffuse white matter (WM), such as the corpus callosum (CC), is associated with increased depressive-like behaviors (4, 5)

1 Introduction Myocardial hypertrophy denotes an increase in cardiomyocyte size and ventricular mass that develops when the heart is exposed to sustained mechanical, neurohumoral, genetic, ischemic, inflammatory, or metabolic stress

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