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During normal metabolism, oxygen is utilized with production of reactive oxygen species (ROS) which are severely toxic to cells 5 .These ROS can oxidize the DNA, lipids and proteins with subsequent cellular death 6

Furthermore, nicotinamide adenine dinucleotide phosphate (NADPH), derived from niacin, is crucial in antioxidant defense mechanisms, by aiding in the regeneration of other antioxidants, such as glutathione (13)

Sex differences in acetaminophen-induced acute liver injury and acute liver failure

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The findings highlight how plasma from septic individuals can trigger significant changes in erythrocytes, ultimately leading to eryptosis