Deu 20 mg significantly inhibits CYP2C19, reducing the conversion of clopidogrel to its active antiplatelet metabolite thereby substantially reducing its antiplatelet efficacy and potentially increasing the risk of adverse cardiovascular events (heart attack, stroke, stent thrombosis) in patients with coronary artery disease
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Excessive burden of ROS, failure of clearance mechanisms and even lack of antioxidants may lead to the accumulation of ROS and to oxidative stress [40], which are associated with genetic damage and breast cancer onset [61,62,63,64,65]
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That said, tolerability is broadly similar across the three compounds: gastrointestinal adverse events dominate, and slow titration is the universal strategy for managing them