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The glucose-dependent insulinotropic polypeptide receptor (GIPR) functions similarly but may also be expressed in - and possibly -cells, modulating glucagon and somatostatin secretion (Shilleh et al., 2024)
Peripheral or ventricular exogenous drug application can likely allow for stimulation of most GLP-1R-expressing cell populations simultaneously
doi:10.1177/0003319715602414 8
10.1016/0009-3084(87)90064-8 Chem
Weight regain risk is highest in the first 3 to 6 months after stopping, with some patients reporting 30-50% of lost weight returning during this window
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