~50% of commercial plans include some GLP-1 coverage Retatrutide insurance coverage / not applicable until approval Wegovy mechanism / GLP-1 receptor agonist (single target) Retatrutide mechanism / GLP-1, GIP, and glucagon triple receptor agonist The Efficacy Gap Between These Two Drugs Is Real Retatrutide delivered markedly greater percentage weight loss in its phase 2 trial than Wegovy showed in STEP-1, though the trials were not head-to-head and differed in design, duration, and population
Many people use it to manage obesity, which is a health condition that can lead to other serious problems like heart disease and diabetes
If the standard range is 200 to 300 mcg, begin at 100 to 150 mcg for the first week
The P values from the hypothesis tests and the widths of the intervals have not been adjusted for multiplicity
As Healio previously reported from the ACHIEVE-1 trial, orforglipron (Foundayo, Eli Lilly), a small molecule oral GLP-1, conferred greater decreases in HbA1c and body weight at 40 weeks than placebo for adults with type 2 diabetes