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the elderly, strict vegetarians (i.e., vegan), and patients with malabsorption problems are more likely to become deficient
K-means clustering analysis of amplicon sequence variants by animal demonstrated that NNMTi-treated DIO mice switched to LD had a distinct microbiome pattern that was highlighted by decreased Erysipelatoclostridium and increased Lactobacillus relative abundances compared to vehicle counterparts
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The cells also become more resistant to lipolysis, the breakdown of stored fat for energy
However, the oral route cannot be excluded as it did not depend on intrinsic factors only, as the simple diffusion (without the need for intrinsic factors) is now considered another mechanism for the absorption of vitamin B12 [49, 50]
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