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Further research indicates that, in HG-induced rat retinal Mller cell (rMC-1) and db/db mouse models, Panax ginseng saponin R1 (NGR1) increased the levels of PINK1 and Parkin in the retina as well as in rMC-1 cells of db/db mice, increased the LC3-II/LC3-I ratio, and decreased the levels of p62/SQSTM1, however, knockdown of PINK1 eliminated the protective effect of NGR1, inferring that NGR1 prevents DR through PINK1-dependent enhancement of mitophagy [158]

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The CMDI, serving as a macroscopic assessment of extensive injury in the specimens, was markedly increased in the DSS group