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The glutathione peroxidase pathway is further regulated by System Xc-, an amino acid antiporter consisting of a disulfide-linked heterodimer of xCT/SLC7A11 and SLC3A2/4F2hc/CD98, and is inhibited by the ferroptosis inducer erastin (4)
Different drug class, different risk profile, but neither is safe with heavy drinking
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With no head-to-head data, comparing the two requires stitching together studies that differ in species, model, route, endpoint, and molecule a chain with several weak links
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