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Without changing any parameters except for the dose, the human model was validated against four separate datasets (see section 4.3.2) with different PO doses 250mg dose dataset from Chung [36] with one 375mg pre-dose 12 hours before the main dose, 500mg dose dataset from Gusler [37] without a pre-dose, 750mg dose dataset from Wen [38] with one 500mg pre-dose 12 hours before the main dose and a 500mg multiple dose dataset from El Messaoudi [39] with six pre-doses of 500 mg with a time interval of 12h