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The lipid tail allows semaglutide to bind reversibly to serum albumin, which slows renal clearance and gives the peptide a half-life of approximately one week, supporting once-weekly subcutaneous dosing in published pharmacokinetic studies

Wegovy can cause nausea, especially during dose increases

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Key Takeaways Retatrutide reduced liver fat by 81-86% at higher doses (8mg and 12mg) in a 48-week phase 2 trial

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