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Further, polyunsaturated fatty acids (PUFAs) are essential precursors for lipid peroxidation in ferroptosis
In addition, sorafenib, a kinase inhibitor approved for the treatment of RCC and HCC, inhibits SLC7A11 to suppress the growth of these tumors via the induction of ferroptosis 67,68
Proinflammatory cytokines further stimulate ROS overproduction aggravating ARDS and lung damage causing a vicious circle between oxidative stress and cytokine storm
Metabolic effects of intermittent fasting
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