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Who May Be a Better Candidate for Each Approach Standard titration may be a fit for those who tolerate the GI side effects reasonably well, want to reach therapeutic doses efficiently, and are following a structured program with regular provider check-ins
If constipation is already severe at 1.0 mg, escalating to 2.4 mg is likely to make it intolerable
& Lavie, C.J
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Pentose phosphate pathway The PPP diverges at the first step of glycolysis, which serves as the largest contributor of cytosolic NADPH and NADPH generation undergoes three irreversible reactions in the PPP oxidative branch
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