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Notably, the lower weight loss (-13.7%) observed in REDEFINE 2 among individuals with T2D suggests that the magnitude of benefit achieved with combined GLP-1 and amylin receptor agonism may depend on the underlying metabolic status, highlighting the need for a more nuanced understanding of the mechanisms governing treatment response [13]
Side effects such as upper respiratory infection, low white blood cell count, and suicidality necessitate more extensive trials to confirm safety (Papp 2012
None are randomized controlled trials
ISSN 1663-4365
Serena Williams opens up on GLP 1 weight loss journey and 31 pound drop before US Open (Image via Getty) Serena Williams, the retired tennis legend, age 43, says she used a GLP-1 weight-loss medication to lose 31 pounds in eight months
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