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10.1158/0008-5472.CAN-05-1925 33 Elrod J
Increased toxicity of a pharmacologically active metabolite of irinotecan (SN38) has been described in patients suffering from Gilberts syndrome as UGT1A1 is the main enzyme responsible for the formation of the inactive SN38 glucuronide (Wasserman et al., 1997)
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