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Conversely high doses, and/or inadequate removal of ROS caused by several mechanisms, i.e., ionizing radiation, bioactivation of xenobiotics, inflammatory processes, increased cellular metabolism, activation of oxidases, and oxygenases, can be very dangerous, modifying susceptible molecules including DNA, lipids, and proteins

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However, this same mechanismfood sitting longer in the stomachis also the root cause of many common gastrointestinal side effects like nausea, vomiting, bloating, and reflux, especially if large meals or slow-digesting foods (like high-fat items) are consumed