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The dose is individualised based on thyroid function tests, with the goal of normalising TSH levels (typically 0.44.0 mU/L, though target ranges may vary based on individual circumstances, including age and cardiovascular status)
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Receptor trafficking involves the internalisation of the active receptor: Ligand complex towards endocytic compartments, followed by its deactivation/dephosphorylation and recycling back to the cell membrane, leading to its re-sensitisation, or trafficking to lysosomal organelles for its degradation and final signal termination (McGlone et al., 2021)
Wolpin BM, Bao Y, Qian ZR, Wu C, Kraft P, Ogino S,
