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Interestingly, frameshift mutations disrupting the C-terminal DNA binding interface of PDS5B (c.3939dup and c.3954del) have been identified in gastrointestinal cancers 37 , underscoring the possible significance of the PDS5B DNA binding attribute in tumor suppression, and indicating that cancers harboring PDS5B mutations could be targeted with PARP inhibitors 38
The knob-billed duck is declining in numbers locally, but due to its wide range it is not considered globally threatened by the IUCN
'Ferroptosis, a recent defined form of critical cell death in neurological disorders
doi: 10.1111/bjd.17323
