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In vitro studies using MDCK cells (a model of intestinal epithelial permeability) demonstrated that PLGA nanoparticles significantly enhanced cellular uptake and transport of puerarin across cell monolayers, achieving a permeability coefficient value of 2.83 0.27 10 5 cm/s, which was significantly higher than that observed for free puerarin (0.38 0.07 10 5 cm/s)
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The peptide also modulates serotonergic and dopaminergic systems, which has implications beyond mood
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