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Its high selectivity and efficiency facilitate chemical synthesis 15,16 and prodrug activation 17 , holding great potential to reduce off-target toxicity and address multidrug resistance 18,19
Knockdown of NCAM1 decreases the expression of genes involved in glucose metabolism, and the reduction in their expression sensitizes NOMO shNCAM_3 leukemic cells to treatment with Ara-C in a murine NSG (NOD scid gamma mouse) model
Unlike live bacteria, they don't need to be "alive" to cause harm introduced into the bloodstream, they can trigger fever, inflammation, or septic shock
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