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Cancer treatments significantly elevate OS through multiple mechanisms: chemotherapeutic agents, particularly alkylating agents and platinum compounds, generate excessive ROS directly damaging sperm DNA and membranes (87, 88), while radiation therapy induces both acute and chronic OS states in testicular tissue, leading to prolonged spermatogenic dysfunction (95)
Sugano et al., 2015
Inconsistent dosing Peptides require steady levels
Cultured Bdnf-Luc cortical cells were treated with each compound for 6 h, then luciferase activity was measured in each well
Apoptosis 23:679694 Regina A, Demeule M, Che C, Lavallee I, Poirier J, Gabathuler R, Bliveau R, Castaigne JP (2008) Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2
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