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When it fails, the consequences can be severe

The WT mice had considerably less DNA adducts (molecules that are strongly bonded to DNA that can lead to DNA breaks and mutations) than the KO mice

UAE Research suggests that senescent cells impair proteasome activity in the heart, leading to the accumulation of damaged proteins and reduced cardiac function

Sixth, the ROC analysis and diagnostic cutoff values derived from our data were not validated in an independent external cohort

f , Representative bright-field micrographs of Jurkat SLC25A39 knockout cells transduced with the indicated sgRNA at the end of the cell proliferation assay