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Briefly, metabolites from 1.0-3.0 10 6 CAR T cells were extracted using 0.4 mL of solvent mixture (water: methanol: acetonitrile, 1:2.25:0.75, v/v/v) and 3 freeze-thaw (30 s each) cycles
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Importantly, BBTMA occurs in an anaerobic environment, which suggests that it is catalyzed not by the CntA/B oxygenase, but rather by a novel oxygen-independent enzymatic pathway for the conversion of metabolites of the l-carnitine pathway to TMA
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With this approval, and by launching a generic for Saxenda, we will provide patients in the US the first ever generic GLP-1 product specifically indicated for weight loss, said Ernie Richardsen, senior vice president, Head of US Commercial Generics at Teva
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