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A 10 mg total blend mixed with 2 mL water equals 50 mcg total blend per U-100 syringe unit
A skeptical clinician would note that without bioequivalence data, assumed equivalence to the Phase 3 trials is an extrapolation
It seems safe to conclude that the phenomenon of early worsening of pre-existing Diabetic proliferative retinopathy was secondary to the initial and rapid improvement in glycemic control that occurred in SUSTAIN-6
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