Evidence-Level Clarification: What These Data Doand Do NotShow It is critical to frame the ASCO GI 2026 findings accurately
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The antioxidant properties of several natural compounds related to the activation of NRF-2 have been investigated [43], such as curcumin [97], KIOM-4, Resveratrol, Zinc, Berberine, L-arginine, oleanolic acid, vitamin D, among others, in animal cell cultures, with disagreeing results, mainly focused on the decrease of OS or the increase of elements of antioxidant response through NRF-2 [43]
For lupus patients who do not necessarily need dramatic weight loss but could benefit from reduced inflammation and improved cardiovascular markers, microdosing may offer a favorable risk-benefit ratio
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