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Even if these approaches are successful in many cases, there is still a subset (3%5% of patients) that progress to therapeutically refractive disease, constituting the so-called TC-related deaths due to the lack of effective treatment. In this view, some efforts are ongoing to identify personalized therapy for refractory patients and drug repositioning represents one of the potential alternatives (Xu et al., 2019)

Slow titration prevents the GI intolerance that derails treatment in the first two months

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