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A limited number of observational analyses suggest hormone therapy may modify weight-loss response, but these data are not randomized or causal

Douglas Dieterich, director of the Institute of Liver Medicine at Mount Sinai Health System Icahn School of Medicine in New York , was not affiliated with this study but commented on the findings

However, the effect of SCFAs on PYY secretion from primary colonic cultures has not previously been investigated, and it is unknown whether FFA2-dependent effects on gut hormone release in vitro are relevant in vivo

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