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Developing new drugs involves years of clinical trials, regulatory approvals, and continuous innovation to ensure safety and efficacy

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only administered GLP-1-MK-801 to animals for up to two weeks, so its long-term efficacy and safety require further validation

MRS measured ratios of Glx/NAA and GABA/Glx, on the other hand, are unbiased, are more likely to detect changes in early-stage ALS patients, and can be obtained frequently to understand drug efficacy faster

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