PubMed laboratory research record [PMID: 6134525] PubMed record related to this compound for laboratory literature review
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Tesofensine works centrally: it prevents monoamine transporters from clearing neurotransmitters from the synapse, extending their signalling duration and intensity
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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+