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Since the GLP-1 receptor is often present in the membrane of neural processes, including the axon terminals (Farkas et al., 2021), Rinaman said, it is possible that the GLP-1 receptor made by those cortical and hippocampal neurons is trafficked to their axon terminals in subcortical regions that do receive GLP-1 input

Some patients benefit from a slower titration or temporarily holding at a lower dose to allow the body to adapt

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