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Cellular senescence and senolytics: the path to the clinic | Nature Medicine n.d
Trp53 fl/fl ) or intracolonic induction of colon tumours by submucosal injection of 100 M 4-hydroxytamoxifen (Sigma-Aldrich) in 810-week-old AKP mice (Villin-CreER T2
89,90 These include deficiencies of proteins, vitamins, minerals, and nutrients essential for the synthesis and proper functioning of ALP
Gastrointestinal symptoms are widespread, affecting 80% of patients, and include abdominal pain, bloating, and diarrhea
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