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75 The 1.4 kb increase in the patients telomere length may have resulted from the combination of Epitalon and UCT-MSC-EXs, potentially improving his mitochondrial function and biological age

Mar 1993;32(1):67-70

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Despite the promising therapeutic potential of MSCs for PH, broader large-scale production and clinical application require addressing key challenges of MSCsincluding heterogeneity, tumorigenicity, reduced biological function, and senescence during in vitro culturethrough the following strategies: standardizing MSC preparation and enriching homogeneous subpopulations using flow cytometry and immunomagnetic bead sorting