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Theoretical concerns are not proof of harm, but they identify areas off-target SAM effects, signalling-pathway impacts, and uncharacterised interactions that require study before any conclusion about human safety could be drawn

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That point is supported with the extensive gene expression analysis

Abstract Background Paracetamol is increasingly used as analgesic and to treat patent ductus arteriosus (PDA) in preterm infants, though preclinical data suggest it may potentially harm the developing lung