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The copper ion is what gives the peptide its biological activity: it binds to TGF-beta receptors on fibroblasts, upregulates metalloproteinase inhibitors (TIMPs), and directly stimulates collagen gene expression

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It acts as a shield against environmental damage and free radicals, preventing collagen breakdown.

Although we found an optimized sequence for the FOXO4 FHD-p53 TAD interaction, it did not show senolytic activity by itself (Figure

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