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There is also concern about medication adherence in a population that may struggle with consistent self-care behaviours

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The 28-day (4-week) stability window is the limiting factor

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By starting with very low doses and titrating slowly, some practitioners believe patients may achieve metabolic benefits whilst minimising tolerability issues

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As TGR5-mediated BA signaling also plays a role in the regulation of GLP-1 production, we analyzed the percentage of TGR5-agonistic BAs in the ileum of MMI mice before and after T3 treatment

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