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For example, in fish GPX4 activity contributes to a greater extent to total GPX activity, [19] GPX4a is the most highly expressed selenoprotein mRNA (in contrast to mammals where it is GPX1 mRNA) [20] and GPX4a appears to be highly inducible to changes within the cellular environment, such as changes in methylmercury and selenium status
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The structural similarity between IGF1R and the insulin receptor means LR3 can be used to probe questions about cross-receptor signaling and the metabolic effects of IGF axis activation
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