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2.3 The Metabolic Reprogramming of Cancers Provides Them with Alternative Sources of Glutamate: Via N -Acetyl-Aspartyl-Glutamate (NAAG) and via the Glutaminase II Pathway Two recent studies have uncovered alternative sources of glutamate in cancer

Factors such as initial B12 levels, underlying medical conditions, certain medications, advanced age, and injection frequency can affect the absorption and utilization of B12, possibly shortening the duration of action

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Reed MC, Nijhout HF, Neuhouser ML, Gregory JF, Shane B, James SJ, Boynton A, Ulrich CM: A Mathematical Model Gives Insights into Nutritional and Genetic Aspects of Folate-Mediated One-Carbon Metabolism