10.1155/2017/8510761 111 NeggersY
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The most critical aspect of apathy is the decrease of motivation, and several behavioral assays have been proposed to measure the degree of motivation, for example, the progressive ratio task (Cambre et al., 2023), female encounter test (Ago et al., 2015), latency to enter an arena (Spangenberg and Wichman, 2018), the Switchmaze test (Hartmann et al., 2024), foraging arena test (Xeni et al., 2024) or vision depended behavior (Ortiz et al., 2020)
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First, proteins containing N-methylated lysine residues are degraded by lysosomes or proteasomes to release 6-N-trimethyllysine (TML), in which lysine provides the carbon backbone and nitrogen atom of carnitine, whereas methionine provides the methyl group