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They chose protection of the pool
a specific increase of fibroblast-specific GPX3 expression or a spatial shift from apically secreted soluble GPX3 to interstitial matrix-associated GPX3, reminiscent of what has been observed in a mouse model of influenza pneumonia 33
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To elucidate the relevance of charge and size of the side chain of the scaffold candidate, we replaced Glu170 of ScGrx7 with Asp, Ala or Lys
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