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La randomizzazione stata 1:1:1 a retatrutide 9 mg, retatrutide 12 mg o placebo per 68 settimane
[11] Patients most likely to experience potential anti-inflammatory benefits from Zepbound are those with obesity-related metabolic complications characterized by chronic low-grade inflammation
The mechanisms include direct GLP-1 receptor activation in salivary glands, reduced fluid intake from appetite suppression, GI-related fluid losses, autonomic nervous system changes, reduced chewing stimulation, and mild diuretic effects
Journal of Clinical Medicine, 10(9), 1891
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