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Refrigerate at 36-46 degrees Fahrenheit (2-8 degrees Celsius)

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Phosphorylation of IGF-IR/InsR is elevated in ER+ breast cancer cells resistant to estrogen deprivation and tamoxifen, possibly due to increased secretion of IGF1/2 in these cells and elevated expression of retinoblastoma-binding protein 2 that inhibits IGFBP4/5 by interacting with ER-NRIP1-HDAC1 complex [107,108,109]

DOI:10.4103/1673-5374.320969

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