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If headaches, nausea, swelling, fatigue, or glucose changes begin after several products are introduced, it may be difficult to determine which component is responsible

Nausea, vomiting, and constipation are most common, especially during initial dose titration, and typically improve over time

The co-regulation of the gut microbiome and host genes might play essential roles in metformin gastrointestinal intolerance

Because the stomach empties more slowly, large or rich meals are far more likely to cause discomfort than they would under normal circumstances

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