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The overexpression of DYRK1A in T21 brains may contribute directly to early-onset neurofibrillary degeneration through tau hyperphosphorylation and indirectly through the phosphorylation of alternative splicing factors (Wegiel et al
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NAPQI-alkylated peptides found by database searching were confirmed by using the following criteria: 1) precursor mass error 95%, 3) the presence of one diagnostic production (see Figure 3) (Sleno et al., 2007
10.1016/j.mcna.2021.06.008 185
Jacalyn Sieben, ND Sources: Friedman, S
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