Abdominal tenderness, injection site reactions, thyroid changes, and signs of dehydration are best assessed in person
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Philp and colleagues (FASEB J, 2003, PMID 14500546) showed the LKKTETQ actin-binding motif at residues 17 to 23 is sufficient to promote endothelial cell migration in aortic ring and chorioallantoic assays, and Bock-Marquette and colleagues (Nature, 2004, PMID 15565145) reported integrin-linked kinase and Akt activation in mouse cardiac models
Human efficacy unproven
A standard review would push that to late 2026 or early 2027