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This class of drugs aims to combine the effects of agonism at the GLP1R (glucose lowering, decreased appetite) with those of GCGR activation (increased energy expenditure, reduced food intake), thus potentially providing improved glycaemic control in combination with substantial weight reduction

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Overall, these data point to a requirement of GLP-2R signaling to expand jejunal villi length and circumference, impacting small intestinal weight in response to the increased food intake upon chronic cold housing