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Other monitored potential side effects include Nausea Vomiting Diarrhea Constipation Decreased appetite Transient increases in heart rate Gallbladder-related events (e.g., cholelithiasis) Elevated pancreatic enzymes These side effects typically diminish over time with continued treatment and appropriate dose titration

Science 281 (5381), 13051308

After eating, the body typically releases two hormones GIP and GLP-1

Eur J Nucl Med Mol Imaging 49:913920 Murthy MS, Pande SV (1984) Mechanism of carnitine acylcarnitine translocase-catalyzed import of acylcarnitines into mitochondria

Severe gastroparesis or other severe gastrointestinal disease : Patients with these conditions may experience worsening symptoms due to tirzepatide's effects on gastric emptying