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Esophageal monitoring If you have persistent reflux symptoms for more than 3 months despite adequate treatment, or if you have alarm symptoms (difficulty swallowing, pain with swallowing, unintentional weight loss beyond therapeutic effects, anemia), endoscopic evaluation is appropriate

Eli Lilly's orforglipron is a little different

Patients on Specific Medications: Certain medications, like proton pump inhibitors or metformin, can interfere with B12 absorption, making monitoring and supplementation necessary

& Reis e Sousa, C

And if youre unsure whether or not your insurance will cover brand-name GLP-1 RAs, Eden or Ivy RX may be a better place to start