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Cdt 9 (4), 345359

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Where f u,p is the unbound fraction of the compound (inhibitor) in the plasma, IC 50 is the half-maximal inhibitory concentration, and I in,max is the estimated maximum plasma compound concentration at the liver inlet, which was calculated using Equation 10

The synthesis and recycling of tetrahydrobiopterin (BH4) is a dynamic process, and GTP cyclohydrolase-1 (GCH1) is the rate-limiting enzyme in the biosynthesis of BH4

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