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As with other glutathione peroxidases, GPx1 has a conserved catalytic tetrad composed of Sec or Cys, Gln, Trp, and Asn, where the Sec is surrounded by four arginines (R 57, 103, 184, 185
A bidirectional Mendelian randomisation study was conducted by He et al
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the glutamine-TCA anaplerosis axis together with nutrient-sensing pathways jointly sets the metabolic threshold for pro-inflammatory or tolerance/reparative programs
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