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By binding monomeric G-actin, TB-500 promotes cytoskeletal reorganization in endothelial cells and keratinocytes, facilitating systemic cell migration to injury sites across the body

Extra caution is appropriate in patients with active cancer, recent cancer, unexplained masses, unexplained weight loss, pregnancy, breastfeeding, known allergy to peptide products, active infection, immune compromise, significant liver or kidney disease, active inflammatory or autoimmune disease flares, unusual clotting history, uncontrolled cardiovascular disease, use of chemotherapy or immune-modifying biologic therapy, and competitive athletes subject to anti-doping rules

62 GhibelliL.FanelliC.RotilioG.LafaviaE.CoppolaS.ColussiC.et al (1998)

In vitro (Lash et al., 1986

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